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Semaglutide-Induced Increase in the Pumping Capacity of Collecting Lymphatics is Only Partially Mediated by LEC-Derived Nitric Oxide and Vasodilatory Prostanoids To determine the mechanism by which semaglutide improves lymphatic pumping capacity and to determine the potential, suspected involvement of nitric oxide (NO) and vasodilatory prostanoids, we assessed the functional responses of collecting lymphatic vessels from WT mice to 5 nM semaglutide following a 20-minute pre-treatment with L-NAME (100M) and indomethacin (10M), which inhibit nitric oxide synthase (NOS) and cyclooxygenases-1,2 (COX-1 and COX-2) respectively

doi: 10.1152/ajpendo.1997.273.5.E981 [DOI] [PubMed] [Google Scholar] 22.Turton MD, OShea D, Gunn I, et al

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