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As a disease of aging, many metabolic co-morbidities are managed concurrently with prostate cancer, including diabetes mellitus, obesity, and metabolic syndrome (5-7)
The increased understanding of activation pathways and related ECD conformations may inspire the design of new molecules targeting the ECDECL interface

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Furthermore, Egr1 is involved in metabolic disease and obesity, and the expression of Egr1 is induced by insulin [57]

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