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Some studies indicate that a portion of weight loss associated with GLP-1 therapy includes loss of fat-free mass (Wilding et al., 2021) Preserving lean mass is essential, especially in individuals with diabetes, due to its role in glucose metabolism (Wolfe, 2006

There is a discrepancy between the magnitude of improvement in glycemic control and the weight loss, cardiovascular, and renal benefits obtained in large clinical trials

These data suggest that a mGIPR-Ab/GLP-1 peptideantibody conjugate may act on a different population of cells or via distinct molecular mechanism(s) compared to GIPR agonists like tirzepatide

Patients who have tried structured diet programs, fitness interventions, or behavioral modification without sustained results become stronger candidates, as this history shows commitment and reveals biological resistance to traditional approaches

We shouldnt wait for more adverse events, more contaminated batches or more misled patients before we act

The microbeads are a fat-blocker, but they dont fundamentally change the way that people eat