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Description
Phase 3b open-label design, 751 adults with obesity but without T2D, randomized 1:1 to max tolerated dose of tirzepatide (10 or 15 mg) or max tolerated dose of semaglutide (1.7 or 2.4 mg) for 72 weeks, both on top of behavioral support

Psychiatry 45 , 1318 (1982)
Symptoms include localised injection site redness and swelling, or systemic signs such as widespread hives, facial swelling, breathing difficulty, or cardiovascular collapse

Laque, A

Ultimately, this pioneering research implicates cAMP-dependent pathways within GLP1R-expressing hindbrain neurons as the critical intracellular conduits mediating semaglutides weight-lowering effects
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