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Acute systemic administration of Ex4 (2.4 g/kg, i.p.) significantly reduced cocaine intake during maintenance sessions and attenuated both cue-induced and cocaine-primed reinstatement of drug-seeking behavior
1 Introduction Metformin is a synthetic derivative of guanidine derived from the guanidine alkaloid of the plant named Galega officinalis L

Mechanistically, GLP-1 signaling suppresses M1-associated genes while enhancing that of M2-related genes through activation of signal transducer and activator of transcription 3 (STAT3) (Wan and Sun, 2019)
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Before getting the results, I suspected that the reality of taking the drugs would be messier than the triumphalist headlines
