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A 2026 review in Drugs lays out the clinical tension clearly: maternal obesity + excess gestational weight gain drive major short- and long-term risks for both mother and baby, while lifestyle-only strategies often deliver modest resultscreating a real unmet need

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Conclusions Twenty-four weeks of acarbose monotherapy in newly diagnosed patients with T2D is associated with significantly increased levels of both fasting and postprandial GLP-1 as well as significantly increased NO levels and NOS activity for those patients in whom postprandial GLP-1 levels were increased