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In the 1990s, researchers discovered that Gila monster saliva contains a peptide called exendin-4, which acts like GLP-1 but resists enzymatic breakdown

Nevertheless, the search for orally administrable compounds that retain the impressive properties of GLP-1 receptor agonists persisted (Table 1)

Some workarounds exist

A plateau often signals that dietary habits have drifted or activity has declinedcommon after months of easier weight loss

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Glycemic control, pre-existing cardiovascular disease and risk of major cardiovascular events in patients with type 2 diabetes mellitus: a systematic review with meta-analysis of cardiovascular outcome trials vs intensive glucose control trials