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In this case, medications approved to treat type 2 diabetes may have been used off-label for obesity management because there was a shortage of those that were approved for weight loss, such as Wegovy

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SGLT2i have consistently demonstrated cardiovascular benefits in meta-analyses and recent studies, confirming their robust efficacy regardless of ejection fraction or the presence of diabetes

In 2019 in the USA and 2020 in Europe, an oral dose of a maximum of 14 mg daily of SEM received approval as type 2 diabetes pharmacotherapy [10,21,22] so that doctors can choose the most suitable formulation for the patients necessities (Figure 1) [10]