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Design, synthesis, docking and biological evaluation of chalcones as promising antidiabetic agents

Participants on the highest dose (15 mg) achieved an average weight reduction of 22.9% over three years, marking one of the longest documented sustained weight loss effects in obesity pharmacotherapy

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Providers emphasize that microdosing is not a shortcut or a way to avoid lifestyle changes

Thus, GLP-1R G-protein-biased ligands may offer new and unappreciated advantages in the context of chronic treatment such as promoting adipocyte hyperplasia, restoring insulin responsiveness and long-term glycaemic control while preserving pancreatic -cell function by minimizing the insulin secretory burden

Aim to preserve health gains for as long as possible