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Proper candidate screening, gradual dose escalation, hydration monitoring, and periodic labs mitigate these risks

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Headaches, body aches, and other symptoms Headaches during the first weeks are often related to dehydration or blood sugar fluctuations rather than direct medication effects

The presence of GLP-1R in MCs has been confirmed by multiple research groups, including our own 5,15,16 and ex vivo data have shown that MCs increase their action potential firing frequency after the addition of both GLP-1 and the GLP-1R agonist exendin-4 17
