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Female GLP-1RA users showed increased HSV risk (HR=1.51), and poorly controlled patients (HbA1c7%) had higher HSV risks (HR=1.195)

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Evidence-based comparison of ecnoglutide (cAMP-biased GLP-1 agonist) and semaglutide (selective GLP-1 agonist), including SLIMMER Phase 3, STEP, and SELECT trial data.