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In recombinant cell systems, it activates GIPR with potency similar to native GIP and GLP-1R with reduced but pharmacologically meaningful potency relative to native GLP-1

Dose Adjustment : If fatigue is severe or persistent, healthcare providers may consider slowing the dose-escalation schedule (FDA labeling allows for flexible titration with 2.5 mg increments no more frequently than every 4 weeks) or maintaining a lower maintenance dose that balances therapeutic benefit with tolerability

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Here's a rough timeline (results vary): Week 12: Most adjustment symptoms, including fatigue, are common Week 34: Many people start feeling more like themselves Month 2+: Energy levels often improve as the body adapts Keep in mind: results vary from person to person

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[DOI] [PMC free article] [PubMed] [Google Scholar] 72.Rosenbaum M, Leibel RL