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For dulaglutide users, the corresponding follow-up was, on average, 173 days (median 139 days, IQR 73 to 257 days)

Tirzepatide is a once-weekly glucose-dependent insulinotropic polypeptide and glucagon-like peptide 1 (GLP-1) receptor agonist [8, 9]

Contact your healthcare provider promptly if you experience any of the following after injection: significant swelling or hardness at the injection site that does not resolve within 48 hours, redness that expands beyond two inches from the injection point, warmth or heat radiating from the injection site combined with pain, any discharge from the injection site including pus or cloudy fluid, fever following injection, severe allergic reaction signs including hives or difficulty breathing, or persistent pain that intensifies rather than improving over 24 hours

Animal studies have demonstrated effects on gastric function, gut-brain signaling, and inflammatory pathways that overlap with some GLP-1 mechanisms

M., et al., Multicenter, PlaceboControlled Trial of Lorcaserin for Weight Management, New England Journal of Medicine 363, no

Pancreatitis represents a rare but serious adverse reaction