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If shedding coincides with the most aggressive dose escalation or the steepest weight-loss phase, your prescriber may consider pacing changes while keeping your broader goals on track

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Tirzepatide reduces body weight by increasing fat utilization via the central nervous system-adipose tissue axis in male mice

Tirzepatide is a novel glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist approved by the FDA for the treatment of type 2 diabetes mellitus (Mounjaro) and chronic weight management (Zepbound)

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