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Pfizer terminated lotiglipron in October 2023 due to dose-dependent liver enzyme elevations, and subsequently discontinued danuglipron in April 2025 after a single case of potential drug-induced liver injury was identified in a dose-optimization study

Even indirect associations with misleading claims can create reputational risk in a category that is already under intense regulatory and public scrutiny

Many people experience symptoms like feeling sick, being sick, bloating, runny stools, constipation and even sulphur-smelling burps

doi: 10.1016/j.jdiacomp.2014.01.012 [DOI] [PubMed] [Google Scholar] 73

Metabolic Health: Improves overall metabolic markers including insulin sensitivity and lipid profiles

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