semaglutide glp 1 receptor agonist GLP-1 Signaling and Oral Dysfunction: A Narrative Review on the Mechanistic Basis of Semaglutide-Related Oral Adverse Effects History of glucagon-like peptide-1 receptor

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Cardiovascular effects Heart rate increased in a dose-dependent manner during the first 24 weeks of treatment, with the largest average increase being approximately 6.7 beats per minute at the 12 mg dose

Semaglutide, another GLP-1 analog, has also shown efficacy in MASH (see semaglutide for MASH)

doi: 10.1210/endrev/bnab022

Approaches to improvements in efficacy primarily target additional gut hormones via dual- and tri-agonists, and if Mounjaro provides any indication, dual- and tri-agonists may not be likely to enhance tolerability

Further, some PCPs worry about lack of reimbursement for time spent discussing obesity, but obesity codes are often now reimbursed