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70% for tirzepatide alone

The FDA stated it intends to restrict GLP-1 active pharmaceutical ingredients used in non-FDA-approved compounded drugs that are mass-marketed as alternatives, and it named Hims & Hers directly

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The GLP-1RA group was predominantly female (83%) compared to 51% in the metformin group, and fewer individuals identified as Latino (41.7% vs 69.9%)

Variability in GLP-1R expression across brain regions, metabolic status, sex, CNS penetrance, and biased agonism among different agents further complicates the interpretation of therapeutic effects

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