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It may also reflect individual physiology or gutbrain signaling differences at younger ages. Most importantly of all, their patient is doing well: Her most recent HbA1c was 5.1% (from an initial 8%), her BMI trajectory has significantly improved (35 kg/m 2 ), her sleep apnea has lessened, and her hyperphagia is much better controlled

Registered dietitian Sarah Nash advises: "I encourage clients to prioritize consistent meals with protein, fiber, and healthy fats, as well as avoid skipping meals, stay well-hydrated, and evaluate their sleep habits." Stick to a schedule eat by the clock, not your hunger cues

The cardiovascular benefits demonstrated with GLP-1 receptor agonists such as semaglutide (in the SUSTAIN-6 and SELECT trials) cannot automatically be extrapolated to retatrutide, and direct evidence is still awaited

He receives grant support from MicroVention, Medtronic, Balt, and Insera Therapeutics

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For moderate hyperkalemia (defined by K levels between 5.4 and 5.9 mmol/L), it is recommended to initiate medical therapy to increase K excretion through the gastrointestinal tract or in the urine