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FUNDING: This work was supported by 2015 National Natural Science Foundation of China (81471028)

Twelve weeks treatment with the DPP-4 inhibitor, sitagliptin, prevents degradation of peptide YY and improves glucose and non-glucose induced insulin secretion in patients with type 2 diabetes mellitus

Seeley Levels of glucose in the plasma are determined by the rate at which glucose emerges from the gastrointestinal tract as well as the rate of glucose production by the liver

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The activation process begins as enterokinase, an enzyme produced in the duodenal crypts of Lieberkhn, encounters the pancreatic zymogen trypsinogen

Waiting for FDA approval The most conservative approach is simply waiting