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Sin embargo, la realidad es mucho ms compleja: estos frmacos no son inocuos y no sustituyen a los hbitos saludables: sobre todo la alimentacin equilibrada y el ejercicio fsico

The activation of ROCK1 by leptin is dependent on the JAK2 signaling

10.1186/s13063-019-3259-x 40 Fernandez-MosqueraL.DiogoC

Retatrutide (LY3437943) is a synthetic triple incretin peptide targeting GLP-1, GIP, and glucagon receptors

While these findings provide preliminary evidence of the potential benefit of semaglutide in CUD in real-world populations, further preclinical studies are warranted to understand the underlying mechanism and randomized clinical trials are needed to support its use clinically for CUD

There are documented case reports of extreme appetite suppression and psychiatric complications requiring GLP-1 discontinuation in people with restrictive eating patterns ( Leziak et al., J Psychiatric Research, 2026 )