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This meta-analysis assessed the safety and effectiveness of combinations of SGLT2is+GLP-1RAs with a focus on their cardioprotective effects along with glucose-lowering ability in patients with type 2 diabetes mellitus (T2DM) in a real-world setting
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The combination therapy of GLP-1 receptor agonists and metformin demonstrates superior safety over monotherapy, while revealing novel adverse events and demographic-specific risk patterns, thereby offering reliable evidence to inform clinical practice.
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Key numbers (T2D, semaglutide vs matched controls): NAION RR at 1/3/5 yrs = 1.00 / 0.84 / 0.70
