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Tirzepatide has been evaluated by NICE for obesity management and will have a phased roll-out [6]

Individuals with a personal history of depression, eating disorders, or poorly controlled type 2 diabetes may warrant closer mental health monitoring during treatment

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These dual shiftsneural and metaboliccreate a permissive environment for weight gain independent of calorie intake changes

Cost: Many weight loss medications are not covered by insurance, making them a significant financial commitment

"Two-year effects of semaglutide in adults with overweight or obesity: the STEP 5 trial"