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In pancreatic -cells [58] and ischaemic coronary vascular cells [59], activating GLP-1R promoted mitochondrial respiration, while in astrocytes, GLP-1R activation suppressed mitochondrial oxidative phosphorylation stimulated by -amyloid peptides [60]

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Indeed, it is only with robust and highly reliable data on true levels of drug exposure among individual patients that conclusive judgements can be made in relation to bioavailability and efficacy, leading to more precise dosing regimens

Obesity drugs have become increasingly popular, but are costly The obesity drugs work by targeting hormones in the gut and brain that affect appetite and feelings of fullness

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