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Rare but potentially serious adverse effects include pancreatitis, gallbladder disease, acute kidney injury, and hypersensitivity reactions, although the overall incidence of these events is low

15 There is also evidence that GLP-1 RAs improve renal hemodynamics by increasing renal blood flow and reducing glomerular hyperfiltration, 15 an effect particularly relevant in patients with early diabetic kidney disease

With the growing use of semaglutide, clinicians must remain vigilant for rare adverse effects such as pleural effusions to ensure prompt diagnosis and treatment

However, it's important to know that A1C goals vary from person to person