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Human neuroimaging studies have shown that the striatum is involved in processing RPEs 3,4 and there is considerable animal evidence that midbrain dopamine (DA) neurons fire in a pattern that is consistent with RPEs: 5 increased firing of DA neurons to outcomes that are more positive than expected and suppression of DA response to outcomes that are more negative than expected

Weight loss medications have improved dramatically over the last decade, but Retatrutide has produced numbers that have surprised many obesity specialists

Rapid fat loss reduces the subcutaneous layer that kept skin taut and voluminous

Food and Drug Administration for the treatment of chronic weight management in those with obesity or overweight who have at least one weight-related condition

It is too early to make definitive comparisons

Comparison of the effects of Liraglutide, Tirzepatide, and Retatrutide on diabetic kidney disease in db/db mice