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With basal insulin: blood sugar below 54 mg/dL occurred in 14 to 19% of Mounjaro users depending on dose in SURPASS-5 (Dahl et al., JAMA 2022), versus 13% on placebo plus insulin

If you noticed injection site redness, swelling, or itching with tirzepatide but not with semaglutide (or vice versa), this is normal and reflects the different formulation chemistry rather than an allergy

If you are very lean with minimal subcutaneous fat, pinch the skin to create a fold and inject into the center of that fold

For people who are commercially insured with United Healthcare and without insurance coverage for Zepbound, you may be eligible for the Zepbound Savings Card which provides significant savings

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