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The vast majority (93.87%) of the reporters were consumers

The estimated loss of skeletal muscle in these two major trials (10% or more during 6872 weeks of treatment) approximates the average decline in muscle mass during 20 years of agingrelated muscle loss in adults older than 30 years, estimated at 3%5% per decade (Figure 5)

Nevertheless, the limited number of studies for some outcomes, particularly renal outcomes, suggests that caution is warranted when interpreting these results

Given the concerns identified by CADTH with the submitted analysis in relation to both the data used and the nature of the model provided, it was not possible to conduct a reanalysis

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This drug belongs to a class of antidepressants called serotonin-norepinephrine reuptake inhibitors (SNRIs), which are highly regarded for their effectiveness in treating neuropsychiatric disorders