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Therefore, they do not come with the same assurances of testing, efficacy, and testing as approved pharmaceuticals

1 Department of Endocrinology & Metabolism, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, China, 2 Department of Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, 3 Innovation Center of Medical Basic Research for Brain Aging and Associated Diseases, Ministry of Education, Tongji University, Shanghai, China

Deprescribing when feasible by periodically reassessing the need for multiple agents and tapering any non-essential/non-effective medications through careful review of history and shared decision making

Zepbound (tirzepatide) Zepbound is currently the most effective FDA-approved medication for weight loss

Compounded semaglutide and tirzepatide offer similar active ingredients but with dose flexibility and potentially lower cost

Drastic change in circulating levels and amelioration of sensitivity to gut peptides such as ghrelin and GLP-1 likely contribute to the superiority of bariatric surgeries, such as Roux-en-Y gastric bypass (RYGB) and vertical sleeve gastrectomy (VSG), compared to dietary interventions alone in promoting sustainable weight loss [38,39]
