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In one study, food intake in rats that received a single dose of thioperamide, a H3R antagonist, was significantly less for two days compared to controls (82)
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In AD, A damages microglia, produces inflammatory cytokines and chemokines, and affects surrounding CNS resident cells (astrocytes, oligodendrocytes, and neurons), which may aggravate tau pathology and ultimately lead to neurodegeneration and neuron loss
