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17 Interestingly, GLP-1 levels are elevated in critically ill patients in different chronic inflammatory diseases including CD, UC, metabolic syndrome, coronary artery disease, and heart failure, and have been found to be increased in animal models of inflammatory conditions in response to bacterial stimuli, suggesting a correlation between inflammation and GLP-1 secretion
However, previous large-scale trials comparing intensive versus standard glycemic control, such as ACCORD and ADVANCE, demonstrated that while intensive glucose lowering modestly reduced the incidence of nonfatal MI, it did not significantly reduce CV mortality among patients with T2D (70, 72, 73)

Effects of linagliptin and liraglutide on glucose- and angiotensin II-induced collagen formation and cytoskeleton degradation in cardiac fibroblasts in vitro

Falkentoft, A

One size does not fit all: Understanding microdosing semaglutide for diabetes in multidose pens

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