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Vlahoyiannis A, Giannaki CD, Sakkas GK, Aphamis G, Andreou EA, Systematic Review

Food sits longer in the stomach, contributing to satiety and to the felt experience of bloating, distension, and pressure

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The American Journal of Medicine , 138 (6), 934-940

Peripheral administration of LIRA leads to its localisation in circumventricular organs and the hypothalamic arcuate nucleus, where it promotes the activation of anorexigenic pathways and the inhibition of orexigenic ones