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Clinically, SGLT-2 inhibition can lead to improvements in glycemic control in addition to a loss of approximately 200 to 300 kilocalories per day, which provides a potential benefit of weight loss

10.1016/j.jclinane.2024.111693 [DOI] [PubMed] 18.Jalleh RJ, Plummer MP, Marathe CS, Umapathysivam MM, Quast DR, Rayner CK et al (2024) Clinical consequences of delayed gastric emptying with GLP-1 receptor agonists and tirzepatide

Alpha cell regulation of beta cell function

10.2337/dci18-0033 34 DavisJ.SinghS.SethiS.RoyS.MittraS.RayasamG.et al (2010)

GLP-1, when secreted by L cells, may act in the endocrine (being released into the bloodstream) or paracrine fashion, i.e., stimulating neurons

Although weight-loss specific drugs are now licensed, supply is limited, and as a consequence, off-label prescribing of diabetic drugs has continued to grow (particularly of Ozempic (active ingredient: semaglutide) and Mounjaro (active ingredient: tirzepatide))
