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Clinical trials have yielded mixed results: several studies, including a phase II trial of NLY01, failed to meet primary endpoints for motor progression, with only modest or nonsignificant effects overall [37,38]

Implications for employers : Employers should expect coverage of GLP-1 drugs for obesity to improve population health and employee productivity, but the return on investment from coverage is not likely to lead to lower medical costs now or in the future

doi: 10.1161/JAHA.119.012244

There are also common side effects in all classes of GLP-1s

Recently, to ensure the safety of GLP-1 RA on sarcopenia, a clinical randomized multicenter trial of bimagrumab, an antibody blockade of activin type II receptor inhibitor, alone or in addition to subcutaneous semaglutide is now ongoing (NCT05616013) [113]

What mechanisms behind weight loss remain unclear