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Although total lean mass (baseline 51.3 kg) was also reduced by 2.3 kg and 1.5 kg with semaglutide and canagliflozin, respectively (estimated treatment difference: 0.78 [1.61, 0.04]), the proportion of lean mass (baseline 59.4%) increased by 1.2%- and 1.1%-point, respectively (estimated treatment difference 0.14 [0.89, 1.17])

Participants with diabetes treated with semaglutide did not show restored motivation

The patient's condition improved with pulse-dose steroids, leading to an improvement in liver function tests

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Abruptly stopping semaglutide can lead to appetite rebound and rapid weight regain within weeks
