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For calcium imaging studies, male Naval Medical Research Institute (NMRI) mice (Taconic Biosciences, BomTac:NMRI) were used (aged 1828 days)

Steady-State Exposure Evaluation for Subcutaneous Semaglutide A one-compartment model, similar to the one used to evaluate phase 3 data, was investigated using steady-state data from subcutaneous dosing only in clinical pharmacology trials

McCarty, TR, Jirapinyo, P, Thompson, CC

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However, developers of GLP-2 therapies for chronic IBD will need to address prescriber concerns regarding long-term trophic effects and the necessity for mucosal dysplasia surveillance