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The Emotional Equation: Fear, Stigma, and the Surgery Hesitation Fear is often the last barrier between understanding and action

Although DSM-5 diagnosis is defined through multiple behavioral criteria encompassing impaired control, social dysfunction, continued use despite harm, and tolerance or withdrawal, converging clinical and preclinical evidence indicates that the core pathological feature of SUDs is the progressive loss of control over intake (O'Brien, 2005)

Questions around peak potential have emerged, but concerns may be overstated

High-risk patients need tailored precautions

Based on Phase 3 data, the likely approved doses will be 4mg, 9mg, and 12mg weekly

[DOI] [PubMed] [Google Scholar] 122.Xie Y., Choi T., Al-Aly Z