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Neuroimaging sub-studies provided additional mechanistic insights: functional MRI (fMRI) revealed a reduction in alcohol cue reactivity in the ventral striatum and septal area among patients receiving exenatide, while single-photon-emission computed tomography (SPECT) imaging showed decreased DAT availability in the striatum, caudate, and putamen

The Bridge program could further reduce costs for all patients, including those not on Medicare

In our additional analyses of ophthalmologic end points among the treatment group, both the well-matched cohorts (n = 68 424 per group) with a T2D diagnosis less than 10 years vs greater than 10 years after the index event showed similar incidence of diabetic eye disease over a 2-year follow-up (eg, DME: 5127 [7.5%] vs 5185 [7.6%] events

At the two-year mark, 77.1% of semaglutide participants maintained at least 5% weight loss versus 34.4% on placebo

An individualized approach considering medical history, current health status, and treatment goals is essential for the best outcomes

For example, digestive symptoms often improve within a few weeks
