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Description
These medications have significantly improved pharmacokinetic profiles and are long-acting, requiring only weekly administration

Yaqub A, Smith E, Salehi M

Hyperglycemia may cause vagus nerve dysfunction due to demyelination [38]

Pathophysiological Basis The hypothesis that tirzepatide might exceed GLP-1RA efficacy stems from dual incretin agonism
And emerging data suggest that optimizing the hormonal environment during the menopausal transition more broadly may positively influence weight loss trajectories and body composition outcomes during GLP-1 treatment [17], consistent with the mechanistic picture of restored hormonal signaling creating a more metabolically receptive physiological state

Not exactly conducive to enjoying your time in the saddle
