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Loss of certain subpopulations of vagal nerves shows similar results, where selective denervation of CCK receptor-containing vagal afferents abolished the satiating effects of GLP-1 and CCK, as well as feeding-induced c-fos expression in the NTS [90]

According to the UK SmPC, the most common side effects include: Nausea (very common, affecting more than 1 in 10 people): Usually most pronounced during the first few weeks of treatment and often diminishes with continued use Diarrhoea (common, affecting up to 1 in 10 people): Typically mild to moderate in severity Vomiting (common): More frequent at higher doses Constipation (common): May occur alongside other gastrointestinal effects Abdominal pain or discomfort (common): Relatively frequent during treatment initiation Decreased appetite (very common): An expected effect related to the medication's action Dyspepsia/indigestion (common): May contribute to discomfort after eating Beyond gastrointestinal effects, other recognised adverse reactions include injection site reactions (redness, itching, or swelling at the subcutaneous injection site), fatigue , and dizziness

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All had Type 2 diabetes and took either a GLP-1 or a sodium-glucose cotransporter-2 inhibitor

BMI = body-mass index

The insulin sensitivity index HOMA-IR [=fasting insulin (mU/l) fasting glucose (mmol/l)/22.5] was calculated according to the fasting insulin and glucose concentration 7