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tirzepatide and retatrutide, respectively)

Both medications affect blood sugar levels and digestive processes, making concurrent use potentially hazardous

Sergey Terushkin, MD, FACS As a bariatric surgeon and weight-loss specialist, Ive watched the evolution of obesity treatment for over a decade

On the latter, studies conducted using site-specific brain micro-injections and single-photon emission computed tomography documented a novel regulatory role of the hypothalamic supramammillary nucleus in the regulation of food intake and reward, posing this brain area as one of the main targets of the GLP1/E conjugate, along with the lateral hypothalamus and the nucleus of the solitary tract, whose activation may be responsible for the anorectic, weight-lowering and reward reducing effects of this multi-agonist 51