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Safety: GI AEs: 74% vs 42% AE discontinuation: ~7% vs ~6% Clinical takeaway: High-efficacy weight loss with a once-daily oral GLP-1RA potentially expanding uptake for patients who prefer to avoid injections

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The future will likely require smarter biomarkers, better patient selection and combination therapies aimed at multiple pathways simultaneously

In this article, we review the latest research to highlight when these medications might offer the greatest benefit for patients with substance use disorders.