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Exenatide prolonged the gastric half-emptying time in all diabetic patients without gastroparesis ( n = 20) and worsened the gastric emptying in two of ten diabetics with pre-existing mild gastroparesis [56]

Patients with chronic gastrointestinal symptoms may also experience rapid weight loss, muscle wasting, fatigue, and worsening nutritional deficiencies over time

2-11 Modest reductions in weight of 5 to 10% can produce clinically significant improvements in CVD risk factors

In addition, GLP-1R overexpression results in improved cognitive function in mice and GLP-1R knockout severely impairs cognitive ability (117, 118)

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During the first year after treatment began, 27.0% of patients reduced their BMI by less than 5%, 22.4% lost between 5% and less than 10%, 14.1% lost between 10% and less than 15%, and 15.8% reduced BMI by at least 15%