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Morphological studies demonstrated a particularly high density of GLP-1R expression in the PVN of mice (Cork et al., 2015), rats (Merchenthaler et al., 1999

MHRA Drug Safety Update: GLP-1 receptor agonists reminder of the potential side effects and to be aware of the potential for misuse
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Specifically, beyond the enteroendocrine L-cells of the intestine, GLP-1 is also produced as a neuropeptide by the pre-proglucagon neurons in the brain stem 3
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