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While this extreme outcome is rare with GLP-1 medications, subclinical thiamine insufficiency causing fatigue, irritability, and poor concentration is much more common
doi: 10.4239/wjd.v7.i17.354

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Therefore, it is recommended that patients using oral hormonal contraceptives switch to a non-oral contraceptive method, or add a barrier method of contraception, for four weeks after initiation with tirzepatide and for four weeks after each dose escalation [170]

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