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Most respond well to dose escalation or behavioral intervention

The vagus nerve and the inflammatory reflexlinking immunity and metabolism

Weight changes at this stage are often modest

It works by mimicking cortisol, a naturally occurring hormone produced by the adrenal glands, and is used to treat a diverse range of conditions including rheumatoid arthritis, inflammatory bowel disease, asthma exacerbations, and autoimmune disorders

Its approval by regulatory authorities, such as the Food and Drug Administration (FDA) in the United States, underscores the recognition of obesity as a chronic medical condition requiring comprehensive management strategies

Any significant weight loss, whether through diet, bariatric surgery or pharmacotherapy, involves some lean mass reduction