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Tirzepatide, like many medications, can cause side effects

Of adults receiving tirzepatide who had no or minimal depression symptoms at baseline, 79.4% remained in that category through the end of safety follow-up, 17% reported mild depression symptoms, 2.9% had moderate symptoms, 0.7% reported moderately severe symptoms and 0.1% had severe symptoms

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Clinical Safety Common safety endpoints across the SURPASS trials included adverse events, hypersensitivity reactions, mean changes in pulse, systolic and diastolic blood pressures, and hypoglycemia

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