oral semaglutide nejm and Cardiovascular Outcomes in High-Risk Type 2 Diabetes: @ 🥸 Among persons with type 2 DM and ASCVD, CKD, or both, the use of oral semaglutide was associated with a Oral Semaglutide and Cardiovascular Outcomes

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Over 18 months, the condition occurred in approximately 8 cases per 10,000 GLP-1 users, compared with 4 to 6 cases among comparison groups

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Following the baseline period, the monkeys were treated with escalating doses of semaglutide (up to 0.05 mg/kg) or vehicle subcutaneously twice weekly for two weeks during which period alcohol was not available

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The researchers were able to measureGLP-1 in synovial fluid - the liquid within joint cavities - of patients with inflammatory rheumatic diseases. That matters becauseGLP-1-based therapies typically lead to much higher systemic exposure