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Vest LS, Koraishy FM, Zhang Z, et al

In the pivotal SURPASS-2 trial (n=1,879), tirzepatide at all doses (5 mg, 10 mg, 15 mg) demonstrated both non-inferiority and superiority to semaglutide 1 mg injection for A1C reduction (-2.01% to -2.30% vs -1.86%) and body weight loss (-7.6 to -12.4 kg vs -5.7 kg)

Both effects stem from the same GLP-1 receptor activation that slows gastric emptying

A practical rotation might use different sides of the abdomen, alternate thighs, and reserve the upper arm for times when someone can safely help if your device instructions require it

29min Mar 19, 2026 10

Lab work may be required