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Effects of PYY1-36 and PYY3-36 on appetite, energy intake, energy expenditure, glucose and fat metabolism in obese and lean subjects

[20] Musculoskeletal discomfort (myalgia, limb pain) usually surfaces 12-24 hours after dosing, peaks at 48 hours, and resolves within 72 hours

If you are wondering how long semaglutide takes to work or whether appetite suppression is immediate , most people notice changes within days of the first injection, though weight loss takes weeks to become visible

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Retatrutide achieved approximately 24.2% mean weight loss in just 48 weeks compared to CagriSemas 22.7% over 68 weeks and 23% over 84 weeks