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But for some, it remains disruptive enough to cause dose reductions or treatment discontinuation

Gastroenterology 155 , 443457.e17 (2018)

In individuals with obesity and diabetes, the incretin effect is diminished, contributing to poor glucose tolerance

These observations also elucidate the complex neurobiology of food cravings

When switching to tirzepatide might make sense Tirzepatide (brand name Mounjaro/Zepbound) is a dual GIP/GLP-1 receptor agonist that has shown greater weight loss than semaglutide in head-to-head trials

187 The incretin hormones play a crucial role in maintaining metabolic homeostasis via augmentation of insulin secretion from islet-beta-cells: the incretin effect accounts for 6070% of total insulin released from the pancreas during the postprandial period